Calcium a-Ketoglutaric (CaAKG) is the calcium salt of α-ketoglutaric acid (AKG), and appears as a white crystalline powder. AKG is an intermediate metabolite in the tricarboxylic acid (TCA) energy metabolism cycle. It has various beneficial effects such as preventing osteoporosis, stabilizing the immune system, improving weight gain, extending lifespan, and regulating aging. It holds broad application prospects in fields such as medicine, medical aesthetics, cosmetics, food, and health supplements. However, due to AKG’s strong acidity, its tendency to cause gastrointestinal discomfort, and its relatively low bioavailability, it is often used in the form of synthesized compounds, such as Calcium a-Ketoglutaric.
GET A QUOTE1.What is Calcium a-Ketoglutaric?
Calcium a-Ketoglutaric (CaAKG) is the calcium salt of α-ketoglutaric acid (AKG), and appears as a white crystalline powder. AKG is an intermediate metabolite in the tricarboxylic acid (TCA) energy metabolism cycle. It has various beneficial effects such as preventing osteoporosis, stabilizing the immune system, improving weight gain, extending lifespan, and regulating aging. It holds broad application prospects in fields such as medicine, medical aesthetics, cosmetics, food, and health supplements. However, due to AKG’s strong acidity, its tendency to cause gastrointestinal discomfort, and its relatively low bioavailability, it is often used in the form of synthesized compounds, such as Calcium a-Ketoglutaric.
2.How it Works?
Higher biocompatibility and safety: As a naturally occurring metabolite in the human body, AKG demonstrates excellent biocompatibility and safety. It can be directly absorbed and utilized by the body without undergoing complex conversion processes, thereby reducing the risk of potential adverse reactions.
Multidimensional efficacy: AKG not only promotes energy metabolism and enhances mitochondrial function, but also improves the aging condition of the body from multiple dimensions by influencing amino acid metabolism and promoting collagen synthesis.
Wide applications: High-purity, high-activity AKG is widely used in the wellness industry for lifespan extension, anti-aging, and alleviating muscle atrophy. In the cosmetics field, it can help increase the body’s collagen content.
3.Benefits and Uses
1: Calcium a-Ketoglutaric (AKG) has been introduced as a potential anti-aging metabolite capable of regulating various physiological functions in organisms, thereby extending lifespan and improving healthspan. Unlike other synthetic anti-aging drugs, AKG is a natural metabolite of the tricarboxylic acid (TCA) cycle and is synthesized within the body. It plays a crucial role in cellular energy metabolism, amino acid/protein synthesis, epigenetic regulation, cell differentiation, fertility and reproductive health, as well as the behavior of cancer cells.
2: Studies have shown that as we age, plasma levels of AKG can decrease by up to tenfold. Fasting and exercise, both of which are known to promote longevity, have been confirmed to increase AKG production. However, AKG is not found in a regular diet, making supplementation the only viable way to restore its levels.
Studies have found that oral administration of Akk bacteria can alleviate colitis.
3: As aging progresses, the number and differentiation capacity of stem cells gradually decline, a phenomenon closely associated with the deterioration of tissue integrity and overall health, leading to various age-related diseases. Studies have shown that Calcium a-Ketoglutaric (AKG) plays a significant role in regulating stem cell proliferation and differentiation, thereby potentially contributing to slowing the aging process and extending lifespan.
4:Calcium a-Ketoglutaric anti-aging cream has the ability to improve skin hydration and reduce wrinkles. Studies have shown that Calcium a-Ketoglutaric may enhance skin hydration and barrier function by activating cell proliferation and upregulating the mRNA expression of genes associated with maintaining epidermal function.
5:Studies have shown that Calcium a-Ketoglutaric can alleviate hyperglycemia in diabetes by inhibiting hepatic gluconeogenesis. The specific mechanism involves regulating the serpina1e signaling pathway, which weakens the process of glucose production in the liver, thereby improving the metabolic state of diabetic patients.
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A:Yes, our company accepts sample orders.
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