Sodium hyaluronate, with the chemical formula (C14H20NO11Na) n, is an inherent component in the human body. It is a glucuronic acid and has no species specificity. It is widely present in tissues and organs such as placenta, amniotic fluid, crystalline lens, articular cartilage, and dermis of the skin. It is distributed in the cytoplasm and intercellular space, providing lubrication and nourishment to the cells and cellular organs contained within.
Improve drug efficacy
HA is the main component of connective tissues such as intercellular matrix, vitreous humor, and synovial fluid in the human body. It has the characteristics of retaining water, maintaining extracellular space, regulating osmotic pressure, lubricating, and promoting cell repair in the body. As a carrier of ophthalmic drugs, it prolongs the retention time of drugs on the surface of the eye by increasing the viscosity of eye drops, improves the bioavailability of drugs, and reduces the irritation of drugs to the eyes.
Adjuvant therapeutic effect: It can be directly injected into the joint cavity as a lubricant for the treatment of arthritis. The moisturizing effect of sodium hyaluronate in skin tissue is one of its most important physiological functions, as sufficient moisture makes the skin smooth and delicate. HA has the highest moisture absorption at low relative humidity (33%) and the lowest moisture absorption at high relative humidity (75%), which is suitable for the moisturizing needs of the skin for cosmetics in different seasons and environmental humidities, without a greasy or clogged feeling.
Wrinkle resistance
The moisture level of the skin is closely related to the content of hyaluronic acid. As age increases, the content of hyaluronic acid in the skin decreases, which weakens the skin's water retention function and leads to wrinkles. Sodium hyaluronate aqueous solution has strong viscoelasticity and lubricity. When applied to the surface of the skin, it can form a moisturizing and breathable film, keeping the skin moisturized and radiant. Small molecule hyaluronic acid can penetrate into the dermis layer, promote blood microcirculation, facilitate the absorption of nutrients by the skin, and have a health effect of beauty and wrinkle resistance.
Film forming and lubricity belong to high molecular weight polymers, with obvious lubrication and good hand feel when applied. Large molecules form a breathable thin film on the surface of the skin, making the skin smooth and moist, blocking the invasion of foreign bacteria, dust, etc. Small molecule sodium hyaluronate can penetrate into the dermis, slightly dilate capillaries, increase blood circulation, improve intermediate metabolism, promote skin nutrient absorption, and achieve lubrication and plumpness effects.
Sunscreen and skin damage repair can eliminate reactive oxygen species generated by ultraviolet radiation on the skin surface, protecting the skin from UV damage. At the same time, it can promote the proliferation and differentiation of epidermal cells, and promote skin regeneration at the injured site.
Moisturizing effect
Experiments have shown that compared to these moisturizers, sodium hyaluronate has the highest moisture absorption at low relative humidity (33%) and the lowest moisture absorption at high relative humidity (75%),. This unique property is suitable for the moisturizing effect of cosmetics on the skin in different seasons and humidity environments, such as dry winter and humid summer. The moisturizing properties of sodium hyaluronate are related to its quality, and the higher the quality, the better the moisturizing performance. Sodium hyaluronate is rarely used alone as a moisturizer and is often used in combination with other moisturizers.
Nutritional function
Sodium hyaluronate is an inherent biological substance in the skin, and exogenous sodium hyaluronate supplements the endogenous sodium hyaluronate in the skin. Sodium hyaluronate with lower quality can penetrate into the epidermal layer of the skin, promoting the supply of skin nutrients and the excretion of waste, thereby preventing skin aging and playing a role in beauty and skincare. The maintenance of the skin is more important than other makeup, and has become a modern awareness of beauty.
Repair and prevention
Skin burns or sunburn caused by exposure to sunlight, such as redness, darkening, peeling, etc., are mainly due to the action of ultraviolet rays in sunlight. Sodium hyaluronate can promote the regeneration of injured skin by promoting the proliferation and differentiation of epidermal cells, as well as clearing oxygen free radicals. Pre use also has a certain preventive effect. Its mechanism of action is different from the commonly used UV absorbers in sunscreen. Therefore, when ha is mixed with UV absorbers in sunscreen skincare products, it has a synergistic effect, which can reduce the transmission of UV rays and repair skin damage caused by the small amount of transmitted UV rays, providing dual protection.
The combination of sodium hyaluronate, EGF, and heparin can accelerate the regeneration of epidermal cells, making the skin delicate, smooth, and elastic. When the skin suffers from mild burns, applying water-based cosmetics containing sodium hyaluronate on the surface can alleviate pain and accelerate the healing of the injured skin.
Lubrication and film-forming properties
Sodium hyaluronate belongs to high molecular weight polymers and has strong lubricity and film-forming properties. Skincare products containing sodium hyaluronate have obvious lubrication and good hand feel when applied. After being applied to the skin, a thin film can be formed on the surface of the skin, which gives the skin a good smooth and moist feeling, and has a protective effect on the skin. Hair care products containing sodium hyaluronate can form a thin film on the surface of hair, providing moisturizing, lubricating, hair care, and eliminating static electricity, making hair easy to comb and flowing naturally.
Thickening property
Sodium hyaluronate has a high viscosity in aqueous solution, and 1% of its aqueous solution is gel, which can play a thickening and stabilizing role when added to cosmetics.
pharmacological action
Physiological active substances widely present in animals and humans, distributed in human skin, synovial fluid, umbilical cord, aqueous humor, and vitreous humor. The molecular weight ranges from 500000 to 730000 daltons, and its solution has high viscoelasticity and conformability, making it an adjuvant for ophthalmic surgery. After injection into the anterior chamber, the solution maintains a certain anterior chamber depth, facilitating surgical operations, protecting corneal endothelial cells and intraocular tissues, reducing surgical complications, and promoting wound healing.
Sodium hyaluronate is a fourth generation biomimetic cosmetic additive. Discovered by KARL MEYER in 1934 from bovine vitreous humor, it is a large molecular polysaccharide extracted from bovine vitreous humor. It has three major characteristics: anti-aging and preservation packaging, and the use of biotechnology. Sodium hyaluronate itself is one of the components of human skin and the most widely distributed acidic viscous sugar in the human body. It exists in the matrix of connective tissue and has good moisturizing effects.