Akkermansia muciniphila (Akk) is a mucin-colonizing intestinal commensal bacterium and one of the most abundant microbial species in mammalian guts. As a mucin-degrading bacterium, it colonizes the intestines of humans, mice, and other mammals by utilizing mucin as its sole nitrogen and carbon source. During intestinal colonization, Akk's metabolites interact with the gut barrier, influencing host health through three mechanisms: reinforcing intestinal barrier integrity, modulating metabolic functions in both the gut and circulatory system, and regulating immune responses. Recognized as a promising probiotic, it has been termed the "longevity bacterium" or "lean bacteria" by international science communicators.
GET A QUOTE1.What is Akkermansia Muciniphila?
Akkermansia muciniphila (Akk) is a mucin-colonizing intestinal commensal bacterium and one of the most abundant microbial species in mammalian guts. As a mucin-degrading bacterium, it colonizes the intestines of humans, mice, and other mammals by utilizing mucin as its sole nitrogen and carbon source. During intestinal colonization, Akk's metabolites interact with the gut barrier, influencing host health through three mechanisms: reinforcing intestinal barrier integrity, modulating metabolic functions in both the gut and circulatory system, and regulating immune responses. Recognized as a promising probiotic, it has been termed the "longevity bacterium" or "lean bacteria" by international science communicators.
2.How it Works?
Akk is the first discovered member of the phylum Verrucomicrobia and is a naturally occurring beneficial bacterium in the human gut, accounting for only 3%-5% of the gut microbiota. Because Akk can grow in the intestinal mucus layer and has broad synergistic effects, it can directly influence several important physiological functions of the host, including immunity, metabolism, and inflammation.
No side effects: Akk is a naturally occurring beneficial bacterium in the human body. Since Akk remains in the outer mucus layer and does not penetrate into the inner layer, colonization by a certain abundance of Akk is beneficial. The bacteria promote the natural renewal of the outer mucin layer, and adverse reactions are almost nonexistent in terms of safety.
Wider barrier effect: Akk strains can colonize the intestinal mucus layer and colon, equivalent to colonizing the "atmosphere" of the gut! It is strictly anaerobic, where most probiotics cannot survive, but Akk can be self-sufficient by relying on stored mucin.
3.Benefits and Uses
1: Akk bacteria alleviate inflammatory bowel disease, obesity, and diabetes.
2: Akk bacteria can act on host cells or receptors through their specific metabolites and membrane proteins to protect various intestinal barrier functions and reduce the levels of inflammatory cytokines, thereby maintaining gut health.
Studies have found that oral administration of Akk bacteria can alleviate colitis.
3: Regulate diabetes, delay aging, suppress inflammation, improve metabolism, prevent non-alcoholic fatty liver disease, modulate immunity, and assist in cancer treatment.
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