Mannose, the only glyconutrient used clinically, is widely distributed in body fluids and tissues, particularly in nerves, skin, testes, retina, liver, and intestines. It is directly utilized for glycoprotein synthesis and participates in immune regulation.
GET A QUOTE1.What is D-Mannose?
Mannose, the only glyconutrient used clinically, is widely distributed in body fluids and tissues, particularly in nerves, skin, testes, retina, liver, and intestines. It is directly utilized for glycoprotein synthesis and participates in immune regulation.
2.How it Works?
D-Mannose, a monosaccharide, plays significant roles in various physiological processes and health domains.
In human physiology, D-Mannose serves as a component of many biological macromolecules. It participates in the synthesis of cell surface glycoproteins and glycolipids, which are crucial for cell recognition, intercellular communication, and immune responses. For instance, certain glycoproteins on cell surfaces function like "identification tags," helping the immune system distinguish between host cells and foreign pathogens to initiate defense mechanisms.
For urinary tract health maintenance, D-Mannose demonstrates remarkable efficacy. Urinary tract infections (UTIs), predominantly caused by Escherichia coli, represent common health issues. E. coli possesses specialized fimbriae that recognize and bind to receptors on bladder wall cells, enabling colonization and proliferation. D-Mannose specifically binds to mannose-binding sites on bacterial fimbriae, preventing E. coli adhesion to bladder epithelium. Non-adherent bacteria are subsequently flushed out through urination, effectively preventing and alleviating UTIs. Studies indicate that appropriate D-Mannose supplementation significantly reduces UTI recurrence rates in preventive and adjunctive treatment cases.
Within the digestive system, D-Mannose exerts beneficial effects by modulating gut microbiota balance. The intestinal tract harbors diverse microbial communities that profoundly influence health. Harmful bacteria like Clostridium perfringens may overproliferate, causing indigestion, bloating, or diarrhea. D-Mannose selectively stimulates beneficial bacteria (e.g., Bifidobacterium) growth and activity. As a representative probiotic, Bifidobacterium inhibits pathogenic bacteria, improves intestinal microecology, enhances gut barrier function, and supports normal digestion/absorption. Concurrently, D-Mannose regulates intestinal mucus secretion, which protects mucosal integrity against harmful substances while facilitating nutrient absorption.
From an immunomodulatory perspective, D-Mannose exhibits bidirectional regulatory effects. During immunodeficiency, it enhances immune cell activity—for example, by promoting macrophage phagocytosis. Macrophages, as immunological "scavengers," eliminate pathogens and senescent cells. D-Mannose improves their phagocytic capacity and chemotactic activity for more efficient pathogen clearance. Conversely, during hyperactive immune responses (e.g., allergies or autoimmune diseases), it suppresses excessive inflammation by modulating immune cell functions and reducing inflammatory cytokine release.
In adjunctive disease management, D-Mannose shows potential value. For diabetes, research suggests it may regulate glucose metabolism by influencing insulin sensitivity and cellular glucose uptake/utilization, thereby moderately improving glycemic control. While not a primary treatment, it could complement conventional therapies for better glucose management.
In oncology research, experimental data indicate D-Mannose affects tumor cells by interfering with surface glycoprotein synthesis/function, potentially impeding adhesion, migration, and invasion—key challenges in cancer treatment. This mechanism offers novel therapeutic insights, though current evidence remains limited to laboratory and clinical trial stages, requiring further validation.
Within the food industry, D-Mannose serves as a low-intensity sweetener (less sweet than sucrose) for sugar-restricted diets, while its humectant properties prevent food desiccation, extend shelf life, and improve texture.
In summary, D-Mannose demonstrates multifaceted importance in human physiology, urinary/digestive health, immune regulation, adjunctive therapies, and food applications. Continued research promises to reveal additional functions and clinical potentials.
3.Benefits and Uses
Mannose, the only carbohydrate nutrient used clinically, is widely distributed in body fluids and tissues, particularly in nerves, skin, testes, retina, liver, and intestines. It is directly utilized for glycoprotein synthesis and participates in immune regulation. Many diseases result from deficiencies in enzymes involved in mannose glycosylation.
Its physiological effects in humans include:
Immune system regulation
Four types of receptors on macrophage surfaces that capture antigens all contain mannose components
Enhanced wound healing
Anti-inflammatory effects
Inhibition of tumor growth and metastasis, improved cancer survival rates
Prevention of certain bacterial infections, such as urinary tract infections
Q:Does the company accept sample orders?
A:Yes, our company accepts sample orders.
Q:What is the minimum order quantity for the company?
A:We do not have a minimum order quantity requirement, we arrange according to the customer's needs.
Q:How to ensure the quality of goods?
A:We have a strict QC/QA management system and strict release procedures, and we will provide all procedures to customers before shipment according to their requirements.
Q:Can we see the product quality before the order is shipped?
A:Of course, we always provide a relative Batach (s) 'COA before shipping.
Q:How will you deliver the goods?
A:We will communicate with customers, adopt their suggestions, arrange the most suitable delivery method, and ensure mutual satisfaction.
