Melatonin, a hormone synthesized by the pineal gland from tryptophan, is best known for its role in improving sleep. The secretion of melatonin by the pineal gland shows a strong physiological cycle, which is related to the alternation of day and night, with less secretion during the day and more secretion at night. The pineal gland reduces the number of awakenings during sleep by shortening the time of awakening before going to bed and the time of falling asleep; by shortening the stage of light sleep and prolonging the stage of deep sleep, the threshold of awakening in the next morning is lowered. So what are the effects of melatonin? Let's take a look below.
Efficacy of melatonin
1. Improve primary sleep disorders
Melatonin can help reduce the waiting time before falling asleep, increase the total sleep time, and improve the overall sleep quality. In addition, although melatonin is less effective in improving sleep disturbance than insomnia drugs, it causes relatively few side effects.
2. Improve secondary sleep disorders.
Melatonin reduces the time required to fall asleep and increases the total sleep time, but it does not significantly help sleep efficiency.
3. Beneficial blood sugar control
Supplementation of melatonin can reduce fasting blood sugar and improve quantitative insulin sensitivity detection index, but it has no obvious help in improving insulin levels, insulin resistance homeostasis model assessment, and glycosylated hemoglobin levels.
4. Adjuvant cancer treatment
The combined use of melatonin in addition to cancer treatment methods (including chemotherapy, molecular target therapy, radiotherapy and supportive treatment) can further improve the tumor remission rate and overall survival rate. In addition, melatonin reduces the incidence of neurotoxicity, thrombocytopenia, and frailty associated with chemotherapy.
5. Adjust jet
lag Melatonin can help prevent or reduce jet lag syndrome, and it seems safe to take it occasionally for a short period of time, and the more time zones you cross (especially eastward flight 2 to 4 time zones), the greater the benefit may be, The benefits of flying westward are generally smaller.
6. Pain relief
Melatonin can significantly reduce the intensity of various pains, including surgery-related pain under local anesthesia, surgery-related pain under general anesthesia, inflammatory pain, procedural pain, and experimental pain.