Efficacy and role of Ginkgo biloba extract

Apr. 06. 2023

Ginkgo biloba extract  has a strong antioxidant effect, can remove excess free radicals in the body, prevent lipid peroxidation in the body, expand coronary vessels, increase cerebral blood flow, enhance platelet activating factor antagonism, and treat vascular aging, cerebrovascular Insufficient blood supply and other neurological diseases. In addition, it also has the effects of improving the body's immunity and delaying aging. Then let's take a look at the efficacy and role of Ginkgo biloba extract.

​Ginkgo biloba extract: bilobalide, pine biflavanone, ginkgo, isorhamnetin, isorhamnetin, ginkgolic acid (15:1), ginkgolic acid (17:1), 7-demethyl ginkgo bis Flavonoids, ginkgolic acid (c15:1), ginkgolic acid (c13:0), ginkgolide j, ginkgolide c, ginkgolide b, ginkgolide a.
Efficacy and role of Ginkgo biloba extract
1. Effect on cardiovascular system
Ginkgo biloba extract can inhibit the activity of angiotensin converting enzyme (ACE) in normal human serum, thereby inhibiting arteriolar contraction, dilating blood vessels, and increasing blood circulation. flow. Ginkgolide is a highly specific PAF receptor blocker. Ginkgo biloba extract or ginkgolide can inhibit platelet activating factor (PAF) and cyclooxygenase or lipoxygenase. Ginkgo biloba extract was well tolerated and antagonized platelet aggregation induced by PAF, but had no effect on aggregation induced by ADP.
2. The effect on the central nervous system
Ginkgo biloba extract affects the endocrine system and the interaction between the immune system and the central nervous system by inhibiting the effect of PAF, which can promote brain circulation metabolism and improve memory function. In addition to improving the lack of memory damage caused by NaNO2, its anti-hypoxic effect may be related to increasing cerebral blood flow and improving brain energy metabolism during hypoxia. Ginkgolide B can be used in the clinical treatment of stroke.
3. The effect on the digestive system
Ginkgo biloba extract can significantly improve the gastric and intestinal ulcers in rats caused by PAF and endotoxin, and can partially inhibit the damage of ethanol to the stomach. Potential therapeutic effect on liver cirrhosis. Ginkgolide B may play a role in the treatment of acute pancreatitis.
4. The effect on the respiratory system
The ethanol extract of ginkgo biloba has a direct relaxing effect on tracheal smooth muscle. The inhalation of nebulized Ginkgo biloba extract not only inhibits bronchoconstriction, but also inhibits the reduction of white blood cells and eosinophils caused by PAF. Ginkgo biloba extract has great significance in inhibiting and treating bronchial hyperresponsiveness.
5. Anti-aging effect
Ginkgo biflavones, isoflavones, ginkgo and quercetin in Ginkgo biloba leaves all have the effect of inhibiting lipid peroxidation, especially quercetin has stronger inhibitory activity.

7. The role of Ginkgo biloba extract in transplant rejection and other immune responses can prolong the survival time of transplanted skin, heterotopic heart xenograft, and orthotopic liver xenograft. Ginkgo biloba extract can inhibit the human body's natural killer cell activity against KC526 target cells, and can also prevent the natural killer cell activity caused by interferon.
8. Anti-tumor effect
The crude extract of Ginkgo biloba leaves, that is, the fat-soluble part, can inhibit EB virus, heptadecene salicylic acid, and ginkgoxanthin have strong inhibitory activity; total flavonoids of Ginkgo biloba can increase the thymus weight and SOD of tumor-bearing mice activity level, mobilize the body's inherent anti-tumor ability; quercetin and myricetin can inhibit the occurrence of carcinogens.
9. Antioxidant effect
Ginkgo biloba extract can directly remove lipid free radicals, lipid peroxidation free radicals and alkyl free radicals, etc., and terminate the free radical chain reaction chain. At the same time, it can also participate in regulating and improving the activity of antioxidant enzymes such as superoxide dismutase and glutathione peroxidase. The antioxidant effect of flavonoids in EGB even exceeds that of vitamins, and it has anti-free radical attack properties in vitro.
Note: The potential efficacy and applications introduced in this article are all from published literature

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